(Note that this is where where "jacket color" begins to break down as a useful identifier – the suit and tie are a little lighter, sure, but it's still the same dang color scheme! Also worth noting that, although the US release mentions France in the subtitle, it's nowhere near as French-focused as the last one was Italy-centric as globetrotting is once again a fixture.)
If Part IV was implicitly modernized, this entry embraces that theme. Technology and hacking are a major focus: the conflict of being a mask-wearing safecracker in an era of digital verification and offsite servers. These are highlighted by new character Ami – a shut-in hacker rescued during their first job who looks for purpose alongside the team. In addition to probing whether a gentleman-thief has become much of a relic as the treasures he used to nab, this Part further explores relationships within the entire gang especially Fujiko and Lupin.
A fun twist this show brings in is that, though it repeats the structure of story arcs broken up by one-shots, these episodes are written in the style of previous Parts with character colors changing to match! This is a fun way to revisit the history for old and new fans alike (even if I have some quibbles with how effectively they evoke their respective Parts):
All that being said, this series is excellent but even if it's better than IV it's harder to recommend this as a starting point – its themes of history and legacy really play a lot stronger if you have some episodes and movies under your belt.
I do not recommend jumping around random episodes of this Part. Some episodes are definitely weaker than others, but overall its semi-serialized nature means that watching straight through is the best way to experience it.